immunophenotypic characterization of peripheral blood t-lymphocytes and their subpopulations in tuberculosis patientsbefore and after treatments
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abstract
tuberculosis is a chronic mycobacterial infection. the main effector cells against mycobacterium tuberculosis are cd4+ t lymphocytes. our objective in this research was to evaluate the quantity of t lymphocytes and their subpopulations before and after treatments with combination of 4 drugs (rifampcin, isoniaside, pyrasinamide, ethambutal) for 2 months directly in sputum-positive tuberculosis patients. twenty patients as cases and 20 healthy people were selected as controls. flow cytometry was used for tcd3+, tcd4+ and tcd8+ lymphocytes by using monoclonal antibodies. our results indicated that there was alteration in cell mediated immunity during tuberculosis showing itself as decrease in tcd3+ and tcd4+ lymphocytes and increase in tcd8+ lymphocytes. the changes in tcd3+ and tcd4+ but not in tcd8+ were reversible after 2 months of treatment.
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Journal title:
iranian journal of allergy, asthma and immunologyجلد ۴، شماره ۱، صفحات ۲۳-۲۶
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